Perfil químico por CLAE-IES-EM e atividade anti-Candida das flores e folhas de Strelitzia reginae (Strelitziaceae)

Authors

  • Wdislaine Pinheiro de Andrade Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil
  • Leonardo da Silva Freitas Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0001-7542-9969
  • Bárbara Cristina Dias Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0001-5482-5145
  • Ana Carolina Estevam dos Santos Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0009-0001-8928-5238
  • Claudemir Oliveira Souza Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0003-4485-9792
  • Mário Machado Martins Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil
  • Júlia Gomes Teixeira Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil https://orcid.org/0009-0008-8611-7424
  • Lucas Andrade de Sousa Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil
  • Carlos Henrique Gomes Martins Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil https://orcid.org/0000-0001-8634-6878
  • Luís Carlos Scalon Cunha Instituto Federal do Triângulo Mineiro, IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0002-4796-2480

Keywords:

Strelitzia reginae, anti-Candida activity, polyphenols, HPLC-ESI-MS

Abstract

Strelitzia reginae é uma planta ornamental de grande relevância para o setor da floricultura e para a economia de diversos países. Na medicinal popular, a espécie é utilizada no tratamento de edemas e inchaços de glândulas associados a infecções sexualmente transmissíveis. Mesmo sendo uma espécie bem conhecida, ainda há um amplo campo para novas investigações quanto às suas propriedades químicas e biológicas. Extratos etanólicos e partições das folhas e flores foram preparados e avaliados pelo método da microdiluição em caldo contra Candida spp.. A partição acetato de etila (PAE) das flores apresentou relevante atividade antifúngica contra Candida albicans, Candida tropicalis e Candida glabrata, com valores de CIM de 23,43, 46,87 e 11,72 μg/mL, respectivamente. Essa partição biaotiva foi analisada por cromatografia líquida acoplada à espectrometria de massas com fonte de ionização por eletrospray (CLAE-IES-EM) e revelou a presença de ácidos orgânicos, ácidos fenólicos, flavonoides, proantocianidinas e benzofenonas. Entre os compostos anotados estão ácido gálico, ácido protocatecuico, catequina, rutina e derivados de quercetina, isoramnetina e kaempferol. Alguns desses metabólitos já foram descritos em S. reginae ou em espécies do mesmo gênero, mas a ocorrência em flores e folhas ainda é pouco relatada. A atividade antifúngica observada para a PAE das flores pode estar associada à presença de compostos fenólicos em sua composição química. Os resultados evidenciam o potencial das flores de S. reginae como fonte de protótipos moleculares para o desenvolvimento de novos agentes anti-Candida, especialmente diante da crescente resistência das leveduras aos antifúngicos convencionais.

Author Biographies

Wdislaine Pinheiro de Andrade, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Wdislaine Pinheiro de Andrade holds a degree in Chemistry Education from the Federal Institute of Triângulo Mineiro. She participated in the Institutional Teaching Initiation Scholarship Program (PIBID) and in teaching, research, and extension projects related to Natural Sciences. Her experience includes research in organic chemistry, natural products, pharmaceutical analysis, and educational technologies.

Leonardo da Silva Freitas, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Leonardo da Silva Freitas holds a degree in Chemistry Education from the Federal Institute of Triângulo Mineiro. He has conducted undergraduate research projects in organic chemistry and natural products chemistry, with an emphasis on the biological activities and chemical characterization of medicinal plant species.

Bárbara Cristina Dias, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Holds a Ph.D. in Analytical Chemistry from the Federal University of Uberlândia. Her research focuses on forensic and food-related samples, emphasizing volatile compound detection, quality control, and the application of optoelectronic noses and tongues. She also has experience in studies involving biological activities and the chemical characterization of medicinal plant species.

Ana Carolina Estevam dos Santos, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Holds a master's degree in Food Science and Technology from the Federal Institute of Triângulo Mineiro. Specialist in Clinical Analysis and Microbiology, with experience in General Pathology and Histotechnology, working in technical activities and supporting teaching, research, and extension programs.

Claudemir Oliveira Souza, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Holds a Ph.D. in Biotechnology from São Paulo State University. Works in the fields of Microbiology and Biochemistry, with expertise in fermentative processes, spectroscopic and biophysical techniques, and biosensor development. His research involves biophysical interactions, heavy metals, and the physicochemical characterization of products of biotechnological interest.

Mário Machado Martins, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Holds a Ph.D. in Chemistry from the Federal University of Uberlândia and completed postdoctoral training in Biotechnology. His work focuses on Natural Products Chemistry and Analytical Chemistry, with expertise in mass spectrometry and spectroscopic techniques. His research includes metabolomics, proteomics, lipidomics, and the application of artificial intelligence in human and animal diagnostics.

Júlia Gomes Teixeira, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Master’s student in the Graduate Program in Immunology and Applied Parasitology at the Federal University of Uberlândia. Her research focuses on the antibacterial activity of peptides against multidrug-resistant bacteria. She has experience in microbiology through participation in undergraduate research projects during her Biomedical Sciences degree.

Lucas Andrade de Sousa, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Currently pursuing a specialization in Advanced Clinical Analysis Techniques at the Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo. Has experience in research projects focused on Bacteriology and Mycology.

Carlos Henrique Gomes Martins, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Holds a Habilitation Degree in Microbiology and a Ph.D. in Clinical Analysis from São Paulo State University (UNESP). He is a Full Professor at the Institute of Biomedical Sciences of the Federal University of Uberlândia and serves in graduate programs in Immunology, Parasitology, and Cell Biology. His research focuses on Microbiology, particularly bacteriology and antimicrobial activity applied to health sciences, and he is a CNPq Research Productivity Fellow.

Luís Carlos Scalon Cunha, Instituto Federal do Triângulo Mineiro, IFTM, Uberaba-MG, Brasil

Holds a Ph.D. in Chemistry from the Federal University of Uberlândia and completed postdoctoral training in mass spectrometry applied to natural products. He is a professor in the Chemistry Teacher Education Program and the Graduate Program in Food Science and Technology at the Federal Institute of Triângulo Mineiro. His research focuses on the chemical characterization and biological activities of natural products.

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Published

2026-09-14

How to Cite

Pinheiro de Andrade, W., da Silva Freitas, L., Cristina Dias, B., dos Santos, A. C. E., Souza, C. O., Martins, M. M., … Scalon Cunha, L. C. (2026). Perfil químico por CLAE-IES-EM e atividade anti-Candida das flores e folhas de Strelitzia reginae (Strelitziaceae). Revista De Ensino, Pesquisa E Extensão Em Saúde, 1(1), 1–12. Retrieved from https://revistas.uniube.br/index.php/epex/article/view/1926

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Vol. 1 No. 1 (2026): Publicação contínua

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Artigos

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