Chemical profiling by HPLC-ESI-MS and anti-Candida activity of the flowers and leaves of Strelitzia reginae (Strelitziaceae)

Autores/as

  • Wdislaine Pinheiro de Andrade Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil
  • Leonardo da Silva Freitas Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0001-7542-9969
  • Bárbara Cristina Dias Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0001-5482-5145
  • Ana Carolina Estevam dos Santos Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0009-0001-8928-5238
  • Claudemir Oliveira Souza Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0003-4485-9792
  • Mário Machado Martins Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil
  • Júlia Gomes Teixeira Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil https://orcid.org/0009-0008-8611-7424
  • Lucas Andrade de Sousa Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil
  • Carlos Henrique Gomes Martins Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil https://orcid.org/0000-0001-8634-6878
  • Luís Carlos Scalon Cunha Instituto Federal do Triângulo Mineiro, IFTM, Uberaba-MG, Brasil https://orcid.org/0000-0002-4796-2480

Palabras clave:

Strelitzia reginae, atividade anti-Candida, polifenóis, CLAE-IES-EM

Resumen

Strelitzia reginae is an ornamental plant of great importance to the floriculture sector and the economy of several countries. In folk medicine, it has been traditionally used to treat edema and swollen glands associated with sexually transmitted infections. Despite being a well-known species, there is still a wide field for further investigations into its chemical and biological properties. Ethanolic extracts and partitions of the leaves and flowers were prepared and evaluated by the broth microdilution method against Candida spp.. The ethyl acetate partition (EAP) from the flowers showed relevant antifungal activity against Candida albicans, Candida tropicalis and Candida glabrata, with MIC values ​​of 23.43, 46.87 and 11.72 μg/mL, respectively. This bioactive partition was analyzed by liquid chromatography coupled to mass spectrometry with electrospray ionization source (HPLC-ESI-MS) and revealed the presence of organic acids, phenolic acids, flavonoids, proanthocyanidins, and benzophenones. Among the compounds annotated are gallic acid, protocatechuic acid, catechin, rutin, and derivatives of quercetin, isorhamnetin, and kaempferol. Some of these metabolites have previously been reported in S. reginae or in species of the same genus; however, their occurrence in flowers and leaves remains scarcely documented. The antifungal activity observed for EAP from flowers may be associated with the presence of phenolic compounds in its chemical composition. The findings highlight the potential of S. reginae flowers as promising source of molecular prototypes for the development of new anti-Candida agents, especially in light of the increasing resistance of yeasts to conventional antifungals therapies.

Biografía del autor/a

Wdislaine Pinheiro de Andrade, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Wdislaine Pinheiro de Andrade es licenciada en Química por el Instituto Federal del Triângulo Mineiro. Participó en el Programa Institucional de Becas de Iniciación a la Docencia (PIBID) y en proyectos de enseñanza, investigación y extensión relacionados con las Ciencias de la Naturaleza. Cuenta con experiencia en investigación en química orgánica, productos naturales, análisis farmacéutico y tecnologías aplicadas a la educación.

Leonardo da Silva Freitas, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Leonardo da Silva Freitas es licenciado en Química por el Instituto Federal del Triângulo Mineiro. Desarrolló proyectos de iniciación científica en las áreas de química orgánica y química de productos naturales, con énfasis en el estudio de las actividades biológicas y la caracterización química de especies vegetales medicinales.

Bárbara Cristina Dias, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Doctora en Química Analítica por la Universidad Federal de Uberlândia. Desarrolla investigaciones en las áreas forense y alimentaria, con énfasis en la detección de compuestos volátiles, el control de calidad y la aplicación de narices y lenguas optoelectrónicas. También cuenta con experiencia en estudios sobre actividades biológicas y caracterización química de especies vegetales medicinales.

Ana Carolina Estevam dos Santos, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Magíster en Ciencia y Tecnología de Alimentos por el Instituto Federal del Triângulo Mineiro. Especialista en Análisis Clínicos y Microbiología, cuenta con experiencia en Patología General e Histotecnología, desempeñándose en actividades técnicas y en el apoyo a la enseñanza, la investigación y la extensión.

Claudemir Oliveira Souza, Instituto Federal do Triângulo Mineiro - IFTM, Uberaba-MG, Brasil

Doctor en Biotecnología por la Universidad Estatal Paulista. Actúa en las áreas de Microbiología y Bioquímica, con experiencia en procesos fermentativos, técnicas espectroscópicas y biofísicas, y desarrollo de biosensores. Sus investigaciones incluyen interacciones biofísicas, metales pesados y la caracterización fisicoquímica de productos de interés biotecnológico.

Mário Machado Martins, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Doctor en Química por la Universidad Federal de Uberlândia, con posdoctorado en Biotecnología. Actúa en las áreas de Química de Productos Naturales y Química Analítica, con énfasis en espectrometría de masas y técnicas espectroscópicas. Desarrolla investigaciones en metabolómica, proteómica, lipidómica y aplicaciones de inteligencia artificial en el diagnóstico humano y animal.

Júlia Gomes Teixeira, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Estudiante de maestría en el Programa de Posgrado en Inmunología y Parasitología Aplicadas de la Universidad Federal de Uberlândia. Desarrolla investigaciones sobre la actividad antibacteriana de péptidos frente a bacterias multirresistentes. Posee experiencia en microbiología adquirida mediante proyectos de iniciación científica durante su formación en Biomedicina.

Lucas Andrade de Sousa, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Actualmente realiza una especialización en Técnicas Avanzadas en Análisis Clínicos en el Hospital das Clínicas de la Facultad de Medicina de Ribeirão Preto de la Universidad de São Paulo. Posee experiencia en proyectos de investigación con énfasis en Bacteriología y Micología.

Carlos Henrique Gomes Martins, Universidade Federal de Uberlândia - UFO, Uberlândia-MG, Brasil

Posee el título de libre docencia en Microbiología y es doctor en Análisis Clínicos por la Universidad Estatal Paulista (UNESP). Es profesor titular del Instituto de Ciencias Biomédicas de la Universidad Federal de Uberlândia y participa en programas de posgrado en Inmunología, Parasitología y Biología Celular. Sus investigaciones se centran en la Microbiología, especialmente en bacteriología y actividad antimicrobiana aplicada a la salud, siendo becario de productividad en investigación del CNPq.

Luís Carlos Scalon Cunha, Instituto Federal do Triângulo Mineiro, IFTM, Uberaba-MG, Brasil

Doctor en Química por la Universidad Federal de Uberlândia, con posdoctorado en espectrometría de masas aplicada a productos naturales. Es profesor de la carrera de Licenciatura en Química y del Programa de Posgrado en Ciencia y Tecnología de Alimentos del Instituto Federal del Triângulo Mineiro. Sus investigaciones se centran en la caracterización química y la evaluación de las actividades biológicas de productos naturales.

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Publicado

2026-09-14

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Pinheiro de Andrade, W., da Silva Freitas, L., Cristina Dias, B., dos Santos, A. C. E., Souza, C. O., Martins, M. M., … Scalon Cunha, L. C. (2026). Chemical profiling by HPLC-ESI-MS and anti-Candida activity of the flowers and leaves of Strelitzia reginae (Strelitziaceae). Revista De Ensino, Pesquisa E Extensão Em Saúde, 1(1), 1–12. Recuperado a partir de https://revistas.uniube.br/index.php/epex/article/view/1926

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Vol. 1 Núm. 1 (2026): Publicação contínua

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